Nanoparticle treatment converts support cells into neurons, alleviating Alzheimer's in mice

A nanoparticle-based drug delivered antibodies that deplete a protein called PTBP1 in mouse brains, converting support cells called astrocytes into neurons. This restored lost neurons and improved cognitive function in mice with an Alzheimer's-like condition. The approach avoids the risks of genetic editing and may be tested in humans within a few years.