Study finds common sweetener xylitol associated with higher cardiovascular risk
A large study presented at the European Society of Cardiology congress found that high blood levels of xylitol, a sweetener used in many products, are linked to an increased risk of heart attacks, strokes, and death. The study of over 17,000 people showed a dose-dependent relationship, with the highest quartile having a 57% higher risk within six years. The association remained even after adjusting for other factors.
The study, presented at the European Society of Cardiology congress in Munich, tracked 17,710 people and found a dose-dependent link between blood xylitol levels and cardiovascular events. Those in the highest quartile faced a 57% higher risk of death, heart attack, or stroke within six years, and an 18% elevated risk over 30 years. The association persisted after adjusting for age, sex, BMI, hypertension, diabetes, and lipid levels. Earlier work by the same team showed xylitol can enhance platelet clot formation, and this new analysis extends that concern to the general population. Xylitol appears in chewing gum, toothpaste, jams, yoghurts, and ice cream, often at levels 1,000 times higher than natural food sources.
This finding could reshape consumer choices and regulatory scrutiny around artificial sweeteners, especially for people with existing heart risks who may use low-calorie products to manage weight or diabetes. If confirmed by further studies, it may prompt health agencies to revisit safety ratings and encourage clearer labeling. However, as an observational study, it cannot prove causation, so individuals should weigh this evidence cautiously rather than panic, while researchers and policymakers consider whether interim guidance is warranted.