Five Potential Upsets to Watch in College Football's Opening Week

College football's Week 0 slate features several intriguing upset opportunities, with North Carolina, NC State, Jacksonville State, and Hawaii all listed as underdogs with potential to win. The article highlights key factors such as quarterback changes and roster turnover that could swing these games. Each matchup offers a chance for a surprising result to start the season.
Week 0 traditionally offers a limited slate, but this year's five matchups carry notable storylines. North Carolina enters under new offensive direction with Bobby Petrino coordinating plays, while quarterback Billy Edwards takes over under Bill Belichick's program. NC State counters Virginia with returning signal-caller CJ Bailey, capitalizing on the Cavaliers' heavy roster losses at key positions. Jacksonville State brings dual-threat quarterback Caden Creel, who accounted for over 2,500 combined passing and rushing yards last season, against FCS powerhouse North Dakota State in its first FBS contest. Hawaii returns quarterback Micah Alejado and receiver Pofele Ashlock after beating Stanford last year, while Memphis fields a rebuilt roster under new coach Charles Huff.
These matchups could shape early-season narratives for several programs, influencing recruiting momentum and fan engagement during the opening weekend. A surprise result may boost a smaller program's national visibility, while losses could intensify scrutiny on coaches facing pressure. Bettors and casual viewers alike may find added interest in games featuring unfamiliar teams, potentially expanding the sport's audience beyond traditional powerhouses.