Fruit fly study reveals distinct gut repair strategies for infection versus dietary changes
A Cornell study using fruit flies found that gut repair differs depending on the stressor: infections kill cells and prompt stem cells to generate replacements, while dietary changes alter the size of existing cells. The research, published in Communications Biology, may inform future treatments for gut diseases like Crohn's and cancer. The findings are preliminary and therapeutic applications are years away.
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The study builds on Buchon's 2009 discovery that bacterial infection triggers both immune responses and stem cell proliferation in fruit fly intestines. By simultaneously manipulating food availability and microbial exposure, the
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Original headline: “Infection kills gut cells, while diet reshapes existing ones, fruit fly study finds.” Browse more stories.