Engineered tRNA Approach Restores Proteins in Cystic Fibrosis Models
University of Toronto researchers engineered transfer RNA to bypass premature stop signals that truncate proteins, aiming at many genetic diseases rather than single mutations. In cystic fibrosis patient-derived organoids, engineered tRNA or Trikafta alone had little effect, but together they restored full-length protein production. The work, published in Science, also restored functional CFTR in human airway cells for more than 40 days and points toward broader preclinical testing.
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... No extra. Plain text. Need maybe no markdown. Good. But check "under 120 words total" for expanded. We have 107. Good. "2 short paragraphs" yes. "under 90 words" context 73. Good. Need ensure not copying source phrasing. Phrases like "premature stop signals" source has "premature stop signal" and "premature stop signals"? It's factual term. "engineered tRNA" source. "Trikafta" source. "full-length protein production" source. Could be considered copying? They said never copying source phrasing. We can alter more. But terms unavoidable. Need original wording. Let's revise to avoid exact phrases? "modified transfer RNA" instead of engineered tRNA. "premature stop signals" is technical. "full-length protein" technical. "patient-derived cystic fibrosis organoids" maybe source summary. Could be okay. But "full-length protein production" exact from summary. We can say "complete protein" maybe. "working CFTR persisted beyond 40 days" source "remained present for more than 40 days" and "f