49ers Injury Report Shows Multiple Starters Questionable For Denver Matchup

The San Francisco 49ers face potential absences of several key players in their Week 4 road game against the Denver Broncos, while Denver has largely cleared its roster for action. The Broncos' injury situation is minimal, with outside linebacker Dondrea Tillman ruled out due to a hamstring injury, while Denver gets back receiver Marvin Mims Jr. after a two-game absence. San Francisco must contend with multiple starter availability issues as it travels to Denver.

San Francisco faces a significant defensive challenge with multiple edge rusher absences. Pro Bowl defensive end Nick Bosa joins defensive ends Mykel Williams in being ruled out due to injuries, potentially leaving the team depleted at a critical position. Additional defensive lineman James Thompson is also unavailable, while pass rusher Keion White remains uncertain ahead of Sunday's contest. The 49ers will attempt to manage this shortage against a Broncos offense that has largely recovered its roster.

Denver enters the matchup in substantially better health. The team cleared most of its active players for participation, with only linebacker Dondrea Tillman sidelined by a hamstring injury. Importantly, the Broncos regained offensive weapons including wide receiver Marvin Mims Jr., whose return from a foot injury restores punt return capabilities and receiving depth after a two-game absence.