MannKind Shares Data Backing Furoscix ReadyFlow for Outpatient Fluid Overload
MannKind announced new analyses of Furoscix ReadyFlow showing comparable urine output to intravenous furosemide for outpatient fluid overload. A randomized crossover study found equivalent total drug exposure at thigh and upper-arm injection sites, with relative bioavailability of 91.3% and 92.7%. The findings were scheduled for presentation at HFSA 2026, and ReadyFlow received FDA approval in July 2026.
MannKind presented analyses at HFSA 2026 in Phoenix (Oct 9–12) examining Furoscix ReadyFlow for outpatient edema in heart failure and chronic kidney disease. A randomized crossover trial found thigh and upper-arm injections met preset equivalence criteria for total drug exposure, with relative bioavailability of 91.3% and 92.7%, respectively. Urine output and urinary sodium excretion were similar across treatments, and tolerability was generally favorable.
A separate post-hoc comparison suggested comparable responses between ReadyFlow and the Furoscix On-body Infusor, though the studies used different populations, limiting direct conclusions. ReadyFlow, an 80 mg/mL autoinjector delivering a full dose in under 10 seconds, received FDA approval in July 2026 for adult fluid overload tied to heart failure or CKD and has launched in the U.S. Listed safety concerns include dehydration, low blood pressure, elevated blood glucose, and hearing problems.
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