Cardinals and Lions Meet in Week 5 With Defenses Under Fire

Arizona will host Detroit in a Week 5 game featuring two defenses that have allowed points in bunches. The Lions are 2-2 and average 29.8 points, but they rank last in yards allowed and second-worst in points allowed, while the Cardinals have lost three straight and surrendered at least 30 in each defeat. FanDuel lists Detroit as a 5.5-point favorite with a 54.5 total, and the analysis expects a high-scoring contest.
Detroit enters at 2-2 while scoring 29.8 points per contest, the league’s fifth-best average. Jared Goff has tossed nine scoring passes without a pick, yet the Lions have both scored and conceded at least 24 in all four outings. Arizona opened with a win but has dropped three in a row, giving up 30 or more each time. Its next seven opponents currently sit at .500 or better.
FanDuel lists Detroit as a 5.5-point favorite and sets the total at 54.5. The research pick favors the over. Kickoff is Sunday at 4:25 p.m. ET on FOX from State Farm Stadium in Glendale, Arizona.
A high-scoring NFL matchup could draw casual viewers and fantasy players, while betting markets may see increased interest around the total. Arizona fans may feel pressure if the skid continues, and Detroit supporters could gain optimism from a road win. Local businesses near Glendale may benefit from game-day traffic, though outcomes are uncertain and should not be treated as predictions.