NFL Week 6 Betting Lines and Matchups Across All 14 Games
Week 6 begins Thursday with Seattle at Denver and includes 14 games, with Cincinnati, Detroit, Miami and Minnesota on bye. The article lists spreads, moneylines and totals for each matchup, including Rams-Cardinals and Chargers-Chiefs. Monday night's finale has San Francisco hosting Washington.
Week 6 starts Thursday, Oct. 15, with Seattle at Denver. Cincinnati, Detroit, Miami and Minnesota are on bye. The rest of the schedule is Sunday, Oct. 18, except Washington at San Francisco on Monday, Oct. 19.
The posted bet365 lines from Oct. 12 include Rams -12.5 vs. Cardinals, Chiefs -8.5 vs. Chargers, Patriots -7 vs. Jets, Colts -7 vs. Titans, and 49ers -7.5 vs. Commanders. Bills-Raiders, Cardinals-Rams and Cowboys-Packers share 52.5 totals.
The release of Week 6 odds may shape how fans, bettors and media discuss the games, especially primetime matchups like Seahawks-Broncos and Commanders-49ers. It could influence wagering interest, sportsbook traffic and conversations around favored teams such as the Rams and Chiefs. For casual viewers, the lines may add context to expectations, while problem gambling risks may remain a concern.