Deebo Samuel Faces Multi-Week Absence With Hamstring Injury

San Francisco 49ers coach Kyle Shanahan said wide receiver Deebo Samuel Sr. is expected to miss at least a couple of weeks with a hamstring injury. Samuel was hurt in the third quarter against Seattle while running toward the sideline, falling and fumbling before being ruled out. Brandin Cooks, who caught a fourth-quarter touchdown, could take on more work while Samuel is sidelined.
San Francisco 49ers coach Kyle Shanahan indicated Deebo Samuel Sr. is expected to miss at least two weeks because of a hamstring issue. The receiver was injured in the third quarter against Seattle while heading toward the sideline; he fell, lost the ball, and was later ruled out.
Samuel returned to the 49ers this offseason on a one-year contract after playing last season with Washington, where he recorded 72 receptions, 727 yards, and five scores. With him unavailable, Brandin Cooks—who scored a fourth-quarter touchdown—may see a larger role.
The injury could affect the 49ers' offensive plans and fans' expectations, while creating opportunities for other receivers. It may also influence fantasy football managers and sports bettors who follow Samuel's production. For broader audiences, the story remains a sports roster update, though it could add attention to player health and workload management in the NFL.