#Aging & longevity

Cellular senescence was initially described as the limited ability of cultured cells to keep dividing, and it later drew attention in cancer research. Scientists came to see that senescent cells build up in older tissues…

A newly formed nonprofit called the Second Century Foundation is working to increase support for research that treats aging as a medical problem. It plans to fill funding gaps by preparing investor-oriented analyses, map…

Functional connectivity reflects synchronized activity across brain regions and is measured by MRI-detected blood flow changes. In two independent cohorts, researchers found that Alzheimer's pathology and cognitive decli…

Senescent cells stop dividing, enlarge, and release inflammatory and growth-promoting signals after stress, injury, or reaching their replication limit. Young immune systems remove these cells efficiently, but they accum…

A large study of U.S. adults aged 50 and older found that those with an ADHD diagnosis were later diagnosed with mild cognitive impairment or dementia more often than others. The article explains that much of the associa…

A large retrospective review found that higher preoperative hemoglobin A1c levels significantly increased the risk of cystoid macular edema after cataract surgery. CME incidence rose from 4.2% in patients with A1c below …

The piece discusses research showing large gaps in life expectancy and healthy years between richer and poorer groups. It suggests that monastic life may remove some of these disparities through shared resources, routine…

This is the weekly Fight Aging! newsletter, which collects news and commentary related to treating age-related disease by targeting aging mechanisms. The issue links to items on muscle fat infiltration, mitochondrial dys…

Researchers argue that the metabolic effects attributed to methionine restriction may instead be driven by lower cysteine levels. Low-methionine diets also reduce cysteine, and methionine can be converted into cysteine, …

Researchers observed that IGFBP5 levels fall in dental follicle stem cells that become senescent. Increasing IGFBP5 reduced senescence and improved osteogenic capacity, apparently through non-canonical Wnt signaling and …

The author reflects on aging and draws on seminars with older women, emphasizing curiosity as a way to stay adaptable and open to learning. She notes that aging well involves integrating loss and gratitude while gaining …

Researchers found that indole produced by gut bacteria worsens the inflammatory immune response after ischemic stroke by activating the aryl hydrocarbon receptor in dendritic cells. In mice, deleting AHR in these cells o…

A new study used speech recordings from 2,928 participants in five Latin American countries to build an aging clock based on acoustic and linguistic features. The resulting speech age gaps separated healthy controls from…

Researchers investigated how succinate dehydrogenase (SDH) influences the heart's limited ability to repair itself after injury. Their work suggests that blocking SDH can alter mitochondrial activity and reduce fibrotic …

Niagen Bioscience said Andrew Shao, Ph.D., has been named the 2026 winner of the Annette Dickinson Trailblazer Award. The recognition comes from Radicle Science and the Council for Responsible Nutrition and highlights hi…

A retrospective U.S. study of more than 187,000 participants found that people with ADHD had over four times the risk of mild cognitive impairment or dementia. Genetic risk for ADHD also predicted cognitive impairment, t…

Emerging diagnostic technologies are exploring the potential of analyzing RNA contained in brain-derived exosomes circulating in blood to identify Alzheimer disease at earlier stages. These blood-based tests offer a mini…

The first FDA-cleared blood test for Alzheimer disease demonstrates promising diagnostic capabilities, but its results can be influenced by various patient factors that may affect interpretation. Dr. George Grossberg eva…

A study of breast cancer survivors found that those who engaged in a structured exercise program demonstrated slower epigenetic aging over 12 months compared to a control group receiving only health education. The findin…

Bexorg has secured a $28 million award from ARPA-H to conduct extended studies on restoring cellular activity in brain tissue after death, building on discoveries from seven years ago that challenged the assumption that …

A key structural component of mitochondrial membranes called cardiolipin naturally declines with age, contributing to the progressive loss of cellular energy production and increased inflammation seen in aging tissues. R…

Hospital-based longevity programs provide comprehensive evaluations designed to assess individual health status and predict aging trajectories. These specialized clinics utilize advanced diagnostic approaches to identify…

A research review identifies chronic inflammatory signaling as an underlying mechanism connecting osteoporosis and neurodegenerative disease, with individuals experiencing bone density loss showing double the risk of cog…

Researchers are investigating fat infiltration into skeletal muscle, known as myosteatosis, as a potential marker for measuring biological age independent of weight changes. The ability to accurately quantify aging throu…

Researchers developed ChromAgeNet, a deep learning algorithm that identifies age-related changes in the structural organization of DNA within blood-forming stem cell nuclei by analyzing microscopy images. The system achi…

Contrary to the longstanding evolutionary psychology theory that human minds are adapted to Pleistocene hunter-gatherer conditions, recent genetic analysis of West Eurasian populations reveals hundreds of genes have unde…

Intergenerational learning between older and younger individuals provides cognitive and emotional benefits that extend beyond standard health recommendations like fitness and diet. The article suggests that mutual sharin…

This weekly newsletter aggregates recent research on aging and longevity science, featuring articles on PD-L1 immune checkpoint modulation in the brain, contextual considerations for mTOR as a drug target, and various ag…

Scientists led by David Sinclair have discovered small molecules that can reprogram cells to a more youthful state, suggesting a potential pharmaceutical approach to aging. The findings raise the prospect that oral medic…

Researchers created gnotobiotic flies colonized with engineered Escherichia coli either capable of or deficient in polyamine biosynthesis to isolate the effects of these bacterial metabolites on host lifespan independent…

Researchers analyzed correlations between epigenetic age acceleration measured in people's 40s and subsequent prospective memory dysfunction approximately a decade later, using data from the National Study of Daily Exper…

Researchers identified that the APOEε2 genetic variant, which offers protection against Alzheimer's disease, strengthens the blood-brain barrier by improving pericyte function and promoting efficient lipid processing in …

A significant challenge in assessing rejuvenation therapies stems from aging having multiple independent causes, meaning treatments targeting one mechanism may show limited effects on overall healthspan or lifespan while…

A new randomized controlled trial in retirement communities found that older adults who walked at faster, more vigorous speeds showed greater improvements in frailty scores compared to those walking at leisurely paces. N…

The article examines cautious academic and pharmaceutical viewpoints on geroscience research, noting that despite billions in funding, questions remain about whether aging can be practically slowed or reversed in humans …

Modern medical technology can sustain bodily functions long beyond the point of meaningful recovery, yet survival rates from in-hospital cardiac arrest remain low, frequently leaving families to make agonizing decisions …

Older adults often struggle more than younger people when attempting to master new skills because their identity is strongly tied to competence and capability, making vulnerability to failure psychologically costly. The …

Celularity announced progress toward the first-quarter 2027 opening of Fontaine Vitale, a regenerative medicine and wellness center in Bali, Indonesia, developed in partnership with Genting Berhad. The facility will be t…

Researchers shielded fruit flies from Earth's geomagnetic field and found that this exposure produced contradictory effects on mitochondrial function and longevity depending on genetic background. In flies modeling Parki…

Long-term care facilities continue to administer potent sedating medications to agitated dementia patients despite federal discouragement of the practice, creating complex decisions for families and guardians. A Michigan…

Dementia caregiving places enormous physical, emotional, and financial burdens on family members, yet society continues treating it as something one person should manage alone—an unsustainable approach. Simultaneously, m…

This commentary examines the idea that persistent activation of the DNA damage response may be a key upstream driver of aging. It proposes that chronic engagement of tumor-suppressor pathways can promote senescence, stem…

A study offers initial evidence that Raman spectroscopy could measure senescent cell burden in tissue without invasive sampling. The authors combined label-free hyperspectral Raman imaging with single-nucleus RNA sequenc…

The article explores how older adults who become homeless after a medical crisis often end up in nursing homes even when they do not need that level of care. It cites research showing that one in 11 nursing home resident…

This is the weekly newsletter from Fight Aging!, which collects news and commentary on treating age-related disease by targeting aging processes. The September 28, 2026 edition highlights topics such as inflammation in a…

Clinics outside regulated markets offer AAV gene therapies delivered locally to muscle or brain, including follistatin, VEGF, telomerase, and SIRT1. Triple Helix researchers report using grip strength as an aging biomark…

The absence of a reliable biological age measure slows progress in testing interventions that might slow aging. A new paper proposes using data from mouse Interventions Testing Program studies to identify shared biochemi…

A new perspective argues that some cognitive changes in later life, such as reduced episodic memory precision, may be adaptive rather than purely compensatory. It proposes that memory systems shift from hippocampal detai…

Type 1 conventional dendritic cells help activate cytotoxic T cells, and their numbers fall with age, weakening immune responses against tumors and pathogens. A new paper synthesizes evidence for a shared mechanism conne…

NewLimit, a South San Francisco-based company, is focused on discovering a new class of drugs that target aging. The company has raised $682 million from investors including Kleiner Perkins and Eli Lilly Ventures. Its co…

A cross-sectional study of U.S. adults aged 62 and older found that prescription and supplement polypharmacy increased between 2015-2016 and 2021-2023, while the proportion experiencing potentially major drug-drug intera…

Researchers surveyed 101 species that live past 250 years, mostly plants, to compare mechanisms of lifespan variation. Both within-species and between-species differences involve DNA maintenance, stemness, and stress man…

The cGAS protein triggers inflammation when it detects cytosolic DNA, contributing to chronic inflammation in aging. In killifish, knocking out cGAS reduced age-related cellular senescence but did not extend lifespan. Th…

In nematode worms, a mild increase in mitochondrial superoxide extends lifespan. Researchers used RNA sequencing and a targeted RNA interference screen to identify 25 kinases required for this effect, including mak-2. Th…

Researchers created mice expressing naked mole rat hyaluronan synthase 2, which produces very high molecular weight hyaluronan. These mice showed improved healthspan and longevity, but no benefit for age-related hearing …

A survey of Americans aged 50 and older found that 72.1% would likely or definitely accept a vaccine that could cut dementia risk by half if they were at high risk. Women and Black adults showed greater hesitation than m…

Researchers warn that the United States may face a shortage of nursing home beds as the oldest baby boomers reach age 80. The growing demand for long-term care is colliding with limited facility capacity, raising concern…

A study of progenitor cells suggests the brain may function as two separate organs, while low-field portable MRI proved useful in clinical and community settings. Blood samples from MS patients showed increased Epstein-B…

A secondary analysis of the SELECT trial found that semaglutide reduced cardiovascular events consistently across frailty levels in adults with heart disease and overweight or obesity. The most frail participants experie…

Many older adults are prescribed benzodiazepines, antibiotics, or daily aspirin despite potential harms outweighing benefits. These drugs can pose increased risks for seniors, and not everyone needs them. Clinicians shou…